Professor Tim Aitman is the Director of the Centre for Genomic and Experimental Medicine within the MRC Institute of Genetics and Molecular Medicine. He is a Professor of Molecular Pathology and Genetics at the University of Edinburgh, the Clinical Director of the HighSeqX facility in Edinburgh Genomics and Consultant Physician in NHS Lothian. Professor Aitman is the co-Director and Edinburgh PI of the Scottish Genomes Partnership, a nationally important collaboration with the NHS, and is also the Director of the Edinburgh-St Andrews Consortium for Molecular Pathology, Informatics and Genome Sciences, one of only six new MRC-EPSRC Molecular Pathology Nodes in the UK.
A graduate of the Birmingham Medical School and Kings College London he obtained his DPhil at Wolfson College in Oxford University. Before joining the University of Edinburgh in April 2014, he was Group Head and Section Chair at the MRC Clinical Sciences Centre, Hammersmith Hospital in London, Honorary Consultant Physician at Hammersmith Hospitals NHS Trust and Professor of Clinical & Molecular Genetics in the Faculty of Medicine of Imperial College London (where he continues as Visiting Professor). Prof Aitman is a Fellow of the Royal College of Physicians, Academy of Medical Sciences and Society of Biology. He is also a Trustee of the Public Health Genomics (PHG) Foundation, a member of several external advisory boards (including the Sir Jules Thorn Medical Advisory Committee and the Wellcome Trust Expert Review Group on Genetics), and editorial board member of Mammalian Genome, Physiological Genomics, BMC Bioinformatics, BMC Medical Genomics and Human Molecular Genetics. He was the Specialist Adviser for the House of Lords Science and Technology Committee's Inquiry into Genomic Medicine, and is currently a member of the Genomics Advisory Board of Health Education England.
Professor Aitman has authored over a hundred scientific papers, many highly cited, and has been invited to give over 150 plenary and state-of-the-art lectures at major national and international conferences. He co-ordinated multiple scientific projects and research consortia with career grant support of over £30 million. In 2007, with the support of Nature Genetics and the Wellcome Trust, he co-founded the “Genomics of Common Diseases” meetings, now a prominent international meeting series in its ninth year. Prof Aitman has also been a mentor of many successful graduate students and postdoctoral scientists.
Targeted next-generation sequencing makes new molecular diagnoses and expands genotype-phenotype relationship in Ehlers-Danlos syndrome.
2016 - Genetics in Medicine [Epub ahead of print]
The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia.
2015 - Nature, Vol:524, Page(s): 356-360
Natural polymorphisms in Tap2 influence negative selection and CD4ratioCD8 lineage commitment in the rat
2014 - PLoS genetics Vol:10, Page(s): e1004151
The use of next generation sequencing in clinical diagnosis of familial hypercholesterolaemia.
2013 - Genetics in Medicine, Vol:15, Page(s): 948-57
Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat.
2013 – Cell, Vol:154, Page(s): 691-703
Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.
2012 - American journal of human genetics, Vol:92, Page(s) 28-40,
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.
2010 – Genome Research, Vol:20, Page(s): 791-803
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.
2008 – Nature Genetics, Vol:40, Page(s): 952-954
Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.
2008 – Nature Genetics, Vol:40, Page(s): 553-559
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.
2008 – Nature Genetics, Vol:40, Page(s): 546-552
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.
2007 – Nature Genetics, Vol:39, Page(s): 721-723
Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans.
2006 – Nature, Vol:439, Page(s): 851-855
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.
2005 – Nature Genetics, Vol:37, Page(s): 243-253
Finding genes that underlie complex traits.
2002 – Science, Vol:298, Page(s): 2345-2349
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.
1999 – Nature Genetics, Vol:21, Page(s): 76-83
Professor of Molecular Pathology and Genetics,
Centre for Genomic & Experimental Medicine,
Institute of Genetics & Molecular Medicine,
University of Edinburgh; and, Honorary Consultant Physician,
NHS Lothian, Crewe Road South,